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https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/2f1b0345-c5b2-4425-b81e-704b7d9c41c9/CleanShot+2023-11-05+at+15.22.50%402x.png Bottlenecks of Aging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/913b9a1e-bc9b-4995-a1c0-1561474ba007/afar.png Bottlenecks of Aging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/33eba6bc-f7bc-474e-aaa5-d8c9af1bc0d6/whitepriority1.jpg Bottlenecks of Aging - Make it stand out Figure 1 — To illustrate the difficulty of demonstrating a benefit on mortality, results of a simulated aging drug trial which enrolls 3,000 40 year old women are shown here. A drug that reduces the relative risk of death by 20% would take about 30 years to establish a statistically significant effect. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/5341eaee-490f-450e-9cf3-95c0971232e1/whitepriority2.jpg Bottlenecks of Aging - Make it stand out Figure 2 — Degeneration of the structure of the brain with age is associated with broad-based declines in cognitive function, even in the absence of overt disease. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/2168fae4-35c9-4170-816e-1cf3c0b22733/whitepriority3.jpg Bottlenecks of Aging - Make it stand out Figure 3 — Reversing age-related tissue and organ damage will require complex, multifactorial interventions that will take decades to perfect. Direct replacement of damaged organs and tissues is another path to rejuvenation that is tractable in the short-term. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/dbf669fd-5e99-4610-8b27-2f48aef43710/courtneyhudsonpaz.jpeg Bottlenecks of Aging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/d37dffc6-43ae-471c-94a5-bb9672f49d08/CleanShot+2023-11-05+at+15.58.37%402x.png Bottlenecks of Aging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/a640964e-1f66-43ff-9c5c-503aaa22a21b/CleanShot+2023-11-05+at+15.59.09%402x.png Bottlenecks of Aging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/914d0457-36df-497d-aa44-f0ce45475b2d/whitepriority4.jpg Bottlenecks of Aging - Make it stand out Figure 4 — Aging is under-researched relative to its importance on health and disease: around five times as many papers are published on cancer per year as compared to aging, even though aging is causally upstream of cancer. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/96088f63-f5e8-42ea-9217-d3a36c0e730e/whitepriority5.jpg Bottlenecks of Aging - Make it stand out Figure 5 —The time period in which you were born affects how long you can expect to live. Advances in therapeutics have led to marked increases in life expectancy for patients with certain previously terminal diseases, like AIDS or cystic fibrosis. Advances in biopreservation techniques could allow many more people who are facing death to benefit from future treatment advances. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/913b9a1e-bc9b-4995-a1c0-1561474ba007/afar.png Bottlenecks of Aging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/d8a76b04-113c-46f4-902b-c9bdfb90f342/whitepriority6.png Bottlenecks of Aging - Make it stand out Figure 6 — In the industrialized drug discovery process, targets feed in at the left of the funnel for new discovery programs. Identifying promising targets is a rate-limiting step for developing new aging drugs. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/5e11b102-1fb4-44bf-8c94-33e97834fca3/whitepriority7.jpg Bottlenecks of Aging - Make it stand out Figure 7 — Animal models of age-associated diseases — like the tg2576 mouse model which overexpresses the amyloid protein that builds up in Alzheimer’s disease — often only recapitulate a subset of the complex phenotypes seen in aged individuals, and are therefore unreliable predictors of efficacy in humans. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/d37fd064-8355-4acb-a6f0-9127db98d634/whitepriority8.jpg Bottlenecks of Aging - Make it stand out Figure 8 — Some forms of damage have been characterized, but we expect that many more are unknown. We have limited means to reverse the forms of damage we are aware of. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/0442b271-4746-4c73-b0d9-278414699464/whitepriority9.jpg Bottlenecks of Aging - Make it stand out Figure 9 — The immortal germline has persisted for billions of years, passed from one body to the next without succumbing to the age-associated damage that affects most somatic cells. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/16a5f981-579c-4e5c-81a4-1816d7bd1d48/whitepriority10.jpg Bottlenecks of Aging - Make it stand out Figure 10 — Advances in tools and techniques have driven progress in our ability to understand, control, and therapeutically intervene in biological systems. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/1cdb0aac-f69c-4253-a25d-3e51ac9cdeff/camera.png Bottlenecks of Aging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/1cdb0aac-f69c-4253-a25d-3e51ac9cdeff/camera.png Bottlenecks of Aging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/1007b5de-0f04-4287-bf92-4142b285f619/whitepriority11.jpg Bottlenecks of Aging - Make it stand out Figure 11 — The idea that humans can – and should – improve their biology is new. New philosophies and narratives are needed to defend it. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/7aa8ed6f-9f1a-4e30-8f13-bf1b0d6c9ba0/raianyromanni.jpg Bottlenecks of Aging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64becfbb6ea1fd445440d59d/1a073164-d477-4dbb-9874-b8079f29ea1d/whitepriority12.jpg Bottlenecks of Aging - Make it stand out Figure 12 — Better datasets help make the invisible economic impacts of aging visible, and inform resource allocation. https://amaranth.foundation/faq daily 0.75 2024-05-21